(Antidepressant Treatment History Form (ATHF)1, Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire (MGH-ATRQ)2) to determine: – dosage, – duration of treatment, and – treatment response • An alternative approach is to focus an adjunctive treatment trial on specific
Apr 11, 2018 · The Massachusetts General Hospital (MGH) antidepressant treatment response questionnaire (ATRQ) Is a self-rated instrument and defines adequate treatment trial as treatment at adequate doses of antidepressants for a duration of 6 weeks.
The Antidepressant Treatment History Form (ATHF) and the Massachusetts General Hospital Antidepressant Treatment Response Questionnaire (MGH ATRQ) are useful instruments to evaluate adequacy of prior antidepressant trials. Another important
There is no consensus about treatment strategies for major depressive disorder with psychosis-like symptoms among Latinos. Guidelines for treatment of major depressive disorder apply to all racial and ethnic groups. Yet it is unclear how to treat psychosis-like symptoms frequently associated with major depressive disorder among Latinos.
METHODS LIMITATIONS • This study was a post hoc analysis of data from 2 randomized controlled trials and as such was not designed to evaluate
MGH Antidepressant Treatment Response Questionnaire (ATRQ) (Chandler et al., 2010), achieved remission per American College of Neuropsychopharmacology (ACNP) Task Force guidelines (Rush et al., 2006a, 2006b) for ≥3 months at any time on the current antidepressant regimen, and then having a recurrence, without dose change for at least the past
major depressive episode (based on Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire [ MGH-ATRQ]) – Participant has a current or prior DSM-5 diagnosis of a psychotic disorder or MDD with psychosis, bipolar or related disorders (confirmed by the MINI), comorbid obsessive compulsive disorder, intellectual
Trazodone is approved by the FDA as a prescription drug used for the medical treatment of depression. Learn about side effects, drug interactions, dosages, warnings, and more.
Sep 20, 2016 · Ketamine, at sub-anesthetic doses, is reported to rapidly decrease depression symptoms in patients with treatment-resistant major depressive disorder (MDD). Many patients do not respond to
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Validated scales such as the Antidepressant Treatment History Form (ATHF; Hazari, 2013; Dew 2005) or the Massachusetts General Hospital – Antidepressant Treatment Response Questionnaire (MGH-ATRQ; Chandler 2010) can be used as an assessment tool combined with corroborating source documents such as medical records, prescription records, etc., to
– MGH-ATRQ and documented by medical history and pharmacy/prescription records, for the current episode of depression. In addition, the participant is taking different ongoing oral antidepressant treatment (on the MGH-ATRQ) for at least the previous 2 weeks at or above the minimal therapeutic dose
ing the Massachusetts General Hospital – Antidepressant Treat-ment Response Questionnaire [MGH-ATRQ]), taking a different oral antidepressant treatment, from previously failed one, for at least the previous 2 weeks, and a MADRS score ≥ 28. Likewise, the exclusion criteria for
A significant minority of people presenting with a major depressive episode (MDE) experience co-occurring subsyndromal hypo/manic symptoms. As this presentation may have important prognostic and treatment implications, the DSM–5 codified a new nosological entity, the “mixed features specifier,” referring to individuals meeting threshold criteria for an MDE and subthreshold symptoms of
dose and duration of the antidepressant therapy was determined as per the MGH ATRQ criteria. The TRD status was confirmed by remote, independent MGH CTNI raters who administered the MGH ATRQ, via teleconference, between the screen and baseline visits. Participants were required to be currently on a stable Fava et al. Page 3 Brain Stimul.
Approximately one-half of patients with major depressive disorder (MDD) will have partial or nonresponse to first-line antidepressant monotherapy, despite receiving an adequate dosage and sufficient duration of treatment. 1 This has led to the definition of treatment-resistant depression (TRD) as a depressive episode that has shown insufficient response to ≥1 trial of an antidepressant that
ATRQ: Efficacy and adequacy. The ATRQ examines the efficacy (improvement from 0% [not improved at all] to 100% [completely improved]), and adequacy (adequate duration and dose) of any antidepressant treatment in a step-by-step procedure. 1,8,9 For a copy of the ATRQ, click here. While conducting the interview, clinicians ask about treatment adherence to each medication trial.
Broad Health Condition Treatment-resistant Depression. Specific Health Condition. Trial Focus Treatment. Recruitment status Completed. Phase of Trial Phase 3. Trial summary. The purpose of this open-label, multicenter study is to assess the long term safety and efficacy of intranasal esketamine plus an oral antidepressant in participants with treatment-resistant depression (TRD).
(MGH-ATRQ). The minimum antidepressant trial for inclusion was 8 weeks, with the last 4 weeks at a stable dose. The study used a 2-stage sequential parallel comparison design, designed to minimize the risk of distortion by a large placebo response and reduce sample size and variability. Patients were initially randomized to receive adjunctive
depressive symptom severity, as assessed by the MGH ATRQ administered by remote, independent raters. An adequate trial is defined as an antidepressant treatment for at least 6 weeks duration at least at a minimum dose as specified in the MGH ATRQ. 5. Patients must have a HAM-D17 ≥ 18 at the end of the screening phase to qualify for inclusion.
The use of atypical antipsychotics as adjunctive treatment for nonresponsive depression is limited by their side effects. This study explores whether pimavanserin can be both an efficacious and tolerable adjunctive treatment for major depressive disorder.
Objective:The lifetime prevalence of psychosis-like symptoms among Latinos living in the United States is 9.5%, and up to 27% of Latinos with major depressive disorder also experience psychosis-lik
An inadequate response is defined as less than (<)50 percent (%) reduction in depressive symptom severity, as assessed by the MGH-ATRQ. An adequate trial is defined as an antidepressant treatment for at least 4 weeks at or above the minimum therapeutic dose specified in the MGH-ATRQ, for any particular antidepressant.
The study population will consist of patients with quiescent CD and UC and IBD-unspecified recruited from the Massachusetts General Hospital Crohn’s and Colitis center. All eligible subjects will have a confirmed diagnosis of CD, UC, or IBD-unspecified according to accepted clinical, endoscopic, radiologic, and histologic criteria.
more) over the past five years, as defined by the MGH-ATRQ – History of inadequate response or poor tolerability to citalopram or escitalopram – Any concomitant form of psychotherapy (depression-focused) – Receiving or have received during the index episode Vagal nerve stimulation, ECT or rTMS, or other somatic antidepressant treatments
Objective To examine the association between exposure to newer antidepressants and risk of gastrointestinal (GI) and other bleeding complications among individuals with major depressive disorder (MDD). Design This study uses an incident user cohort design to compare associations between incidence of vascular/bleeding events and the relative affinity (low, moderate or high) of the
Director, Division of Clinical Research of the MGH Research Institute Executive Vice Chair, MGH Department of Psychiatry Executive Director, MGH Clinical Trials Network and Institute (CTNI) *TRD assessed with ATRQ by site rater prior to enrollment into the prospective lead-in period Data derived from ClinicalTrials.gov. www.mghcme.org
Psychiatrist-in-Chief, Massachusetts General Hospital (MGH) Director, Division of Clinical Research of the MGH Research Institute Executive Director, MGH Clinical Trials Network and Institute (CTNI) Slater Family Professor of Psychiatry, Harvard Medical School
Adequate ADT is defined as a therapeutically sufficient dose for a sufficient treatment period, which would be expected to be effective as listed in the MGH Antidepressant Treatment Response Questionnaire (ATRQ).
measures (e.g. ATHF, MGH-ATRQ) and current symptom severity (Iovenio and Papakostas (2012). Please consider adding into this section acceptable means for assessing treatment failure, including use of clinical history and medical records to document failure. 214-216 TRD is not well defined which is acknowledged by the Agency.
The adequacy of dose and duration of the antidepressant therapy will be determined as per the MGH ATRQ criteria. The TRD status will be confirmed by remote, independent raters from the MGH CTNI who will administer the MGH ATRQ, via teleconference, between the screening visit and the baseline visit.
for the MGH CPFQ, SFI, ATRQ, DESS, and SAFER. * E-mail: [email protected] These authors contributed equally to this work.” These authors also contributed equally to this work. Introduction Intentional behavior, across a spectrum of healthy and disordered conditions such as addiction, is hypothesized to reflect
Participants enrolled in the 8-week trial had to have HAM-D17 total score ⩾18, and a history of inadequate response (6 weeks using adequate dose as specified in the ATRQ) for their current
182 Clinical Psychologist jobs available in Schaumburg, IL on Indeed.com. Apply to Clinical Psychologist, Psychologist, Licensed Clinical Social Worker and more! SCID-CT, MGH-ATRQ, MMSE) who will be screened for clinical trials for Major Depressive
Director, Division of Clinical Research of the MGH Research Institute Executive Vice Chair, MGH Department of Psychiatry Executive Director, MGH Clinical Trials Network and Institute (CTNI) Associate Dean for Clinical and Translational Research Slater Family Professor of Psychiatry, Harvard Medical School Treatment-Resistant Depression (TRD)
Pharmakotherapie mit einem für die Depressionsbehandlung zugelassenen Antidepressivum in einer ausreichenden Dosierung gemäß Fachinformation für mind. 6 Wochen zum Zeitpunkt des Screenings ohne ein ausreichendes Ansprechen nach den Kriterien des MGH ATRQ.
Executive Vice Chair, MGH Department of Psychiatry Executive Director, MGH Clinical Trials Network and Institute (CTNI) Director, MGH Depression Clinical and Research Program Slater Family Professor of Psychiatry, Harvard Medical School Recent Developments in the Psychopharmacology of Depression
A Double-Blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicide Ideation, in Participants Who Are Assessed to Be at Imminent Risk For Suicide.
Objectives: These recommendations were designed to ensure safety for patients with major depressive disorder (MDD) and to aid monitoring and management of adverse effects during treatment with approved antidepressant medications. The recommendations aim to inform prescribers about both the risks associated with these treatments and approaches for mitigating such risks.
Charles DeBattista is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.
As a possible alternative to the HAM-A and BAI, our research team from the Massachusetts General Hospital developed a new measure of anxiety—the Anxiety Symptoms Questionnaire (ASQ). The ASQ is a brief and practical self-report assessment for evaluating the
Objective . We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction (AISD) in women. Method . We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female outpatients (mean age of 41.5 ± 12.5 years) with SSRI/SNRI-induced sexual dysfunction whose depression remitted.
Chandler GM, Iosifescu DV, Pollack MH, et al. RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ). CNS Neurosci Ther 2010; 16:322. Oquendo MA, Baca-Garcia E, Kartachov A, et al. A computer algorithm for calculating the adequacy of antidepressant treatment in unipolar and bipolar
Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, et al. (2010) Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder. and copyright royalties for the MGH CPFQ, SFI, ATRQ
MF holds a patent for the Sequential Parallel Comparison Design (SPCD) and a patent application for a combination of azapirones and bupropion in MDD. Dr Fava has copyright royalties for the MGH CPFQ, SFI, ATRQ, DESS, and SAFER. TD’s research has been funded by NIMH, NARSAD, TSA, and OCF.
ATRQ: Efficacy and adequacy The ATRQ examines the efficacy (im-provement from 0% [not improved at all] to 100% [completely improved]), and ade-quacy (adequate duration and dose) of any antidepressant treatment in a step-by-step procedure.1,8,9 For a copy of the ATRQ, visit this article at CurrentPsychiatry.com.
May 03, 2011 · Objective: Two antidepressant medication combinations were compared with selective serotonin reuptake inhibitor monotherapy to determine whether either combination produced a higher remission rate in first-step acute-phase (12 weeks) and long-term (7 months) treatment. Method: The single-blind, prospective, randomized trial enrolled 665 outpatients at six primary and nine psychiatric
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Royalty/patent, other income: Patents for Sequential Parallel Comparison Design (SPCD) (US_7840419, US_7647235, US_7983936, US_8145504, US_8145505); and patent application for a combination of Ketamine plus Scopolamine in Major Depressive Disorder (MDD), licensed by MGH to Biohaven.
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